Just Published ‘MRI of Joint Infection and Inflammation, with Emphasis of DCE-MRI’ by IAG’ Scientific Leadership & Collaborators

Just Published ‘MRI of Joint Infection and Inflammation, with Emphasis of DCE-MRI’ by IAG’ Scientific Leadership & Collaborators

Inflammation is the hallmark and main driver of both inflammatory and infectious joint diseases, that will lead to rapid destruction of the joint structures if appropriate diagnosis and treatments are delayed. To improve the validity of quantitative imaging biomarkers when diagnosing, monitoring or treating infectious and most inflammatory joint diseases, it is vital to utilize Dynamic Contrast Enhanced MRI (DCE-MRI) over conventional contrast-enhanced MRI. This allows for accurate differentiation of soft and bony tissue from fluid collections and infectious debris and robust extraction of quantitative information regarding blood flow and capillary permeability, especially when dedicated analysis methods and software are used to analyze contrast kinetics.

A extended review by IAG’s scientific team and international group of collaborators just published in PET Clinics: https://lnkd.in/dh7zMz It describes principles of DCE-MRI for the assessment of infectious and inflammatory joint diseases.

Request more information: info@ia-grp.com

Key Points

  • DCE-MRI can provide robust and sensitive quantitative information on perfusion in the joint tissues for diagnosis and monitoring of infectious and most inflammatory joint diseases

 

  • There is increasing evidence of clinical and research utility of DCE-MRI in inflammatory and degenerative joint diseases, and to a lesser degree in septic arthritis and spondyloarthropaties

 

  • High sensitivity and reproducibility of quantitative perfusion markers can be obtained from DCE-MRI in healthy individuals and patients when appropriate post-processing imaging software is used

 

  • Quantitative DCE-MRI perfusion markers correlate highly with synovial vascularity and inflammatory cell infiltrates and allows differentiation of patients with distinct inflammatory joint diseases

 

  • DCE-MRI-based outcome measures show high sensitivity to treatment response following steroid injection and biologic treatments and correlate closely with clinical scores of pain and function in patients with inflammatory and degenerative joint diseases

Therapeutic Areas Discussed:

Authors 

Mikael Boesen, Olga Kubassova, Iwona Sudoł-Szopińska, Mario Mass, Philip Hansen, Janus Damm Nybing, Edwin H. Oei, Robert Hemke, Ali Guermazi

 

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