Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple different organs, including the kidneys and central nervous system. With lupus, the body’s immune system targets its own body tissues. Lupus arthritis affects hands of the patients and lupus nephritis – the kidneys.
IAG’s team is supporting a number of academic and proof of concept trials that develop, test and validate various radiologic methods aiming to improve disease characterization in patients with SLE beyond simple anatomical endpoints.
In clinical trials, imaging biomarkers are used to assess joint inflammation and to be more specific about including a patient intro the trial, as imaging is more specific when added to the clinical assessment.
IAG’s team is actively working with drug developers to determine and help including into the trial inclusion / exclusion criteria, the right methodologies for patient stratification that can help differentiating lupus patients. This especially critical for novel therapeutics targeting early disease.
IAG’s team supported trials that involved various radiological examinations of patients with lupus, such as
- Computed tomography (CT),
- Magnetic Resonance Imaging (MRI),
- Ultrasound (US).
IAG’s team is active in scientific community and have contributed and actively led the developments in physiological non-contrast MRI protocols to assess tissue oxygenation, glomerular filtration, renal perfusion, interstitial diffusion, and inflammation-driven fibrosis in lupus nephritis (LN) patients. Pour radiology team worked on the vessel size imaging (VSI, an MRI approach utilizing T2-relaxing iron oxide nanoparticles) development and nuclear medicine team on the molecular imaging probes used to monitor the disease.
Reach out to our expert team, as you are designing and planning your trial.
About IAG, Image Analysis Group
IAG, Image Analysis Group is a strategic partner to bio-pharmaceutical companies developing new treatments to improve patients’ lives. Our dynamic Strategy, Trial Solutions and Bio-Partnering divisions work closely to meet critical needs of biotechnology companies: funding, clinical development, and monetization of their assets. We fuse decades of therapeutic insights, risk-sharing business model and agile culture to accelerate novel drug development. IAG broadly leverages its core imaging expertise, proprietary technology platform DYNAMIKA and capabilities to support an objective early go no/ go decision and drive excellence for tomorrow’s innovative therapeutic agents with speed.
Contact our expert team: imaging.experts @ ia-grp.com
Experience: Scoring Systems
- Visual MRI Scoring
- Ultrasound Structural Erosion (ScUSSe)
- Quantitative Inflammation (DEMRIQ)
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