Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement
Genome-wide association meta-analysis indicate differences in genetic associations between knee and hip osteoarthritis depending on joint replacement status. Genetic correlations with pain phenotypes tended to be stronger in the non-surgical groups. For the surgical phenotypes, 10 novel variants were identified, including genes involved in autophagy (rs2447606 in ATG7) and mechanotransduction (rs202127176 in PIEZO1).
Title: Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement
Journal: Annals of the Rheumatic Diseases
Authors: Cecilie Henkel, Mikael Boesen and Anders Troelsen
Access Publication Online: http://dx.doi.org/10.1136/ard-2022-22319
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