BRAIN NEURO-INFLAMMATION

BRAIN NEURO-INFLAMMATION

BRAIN NEURO-INFLAMMATION

X-Linked Adrenoleukodystrophy (X-ALD) is a rare inherited peroxisomal neurodegenerative disorder with the following symptoms: central inflammatory demyelination in the brain, axonal degeneration and adrenal insufficiency.

There are two main neurologic phenotypes of X-ALD. The first occurs in both children and adults and is the most serious, called Cerebral X-Linked Adrenoleukodystrophy (cALD). Sufferers experience brain neuroinflammation and early death. However, the most common is Adrenomyeloneuropathy (AMN), a progressive severe motor dysfunction condition that affects young adults.

Whether it presents in children or adults, X-ALD can be recognised by central inflammatory demyelination in the brain, axonal degeneration, and adrenal insufficiency.

 

The severity of the inflammatory process has been correlated with the rapidity of disease progression.

IAG’s team has experience with designing and deliverying clinical trials that involve use of

  • MRI, inc. contrast MRI
  • CT
  • Molecular imaging

Our research has shown that contrast-enhanced T1- weighted spin-echo MR imaging may serve as a marker for the presence and the severity of this inflammatory process.

A very strong association between the presence of contrast enhancement on T1-weighted MR images and X-ALD progression based on clinical evaluation and MR imaging has been demonstrated.

The trials in cALD that were supported by our team have involved MRI as a patient stratification and disease progression tool, with the the following outcome measurements:

  • Loes Score (Percent change from baseline in brain lesions)
  • Monitoring of status of gadolinium enhancement
  • Lesion volume and morphology
  • Qualitative assessment of appearance of Gd enhancing brain lesion on MRI
  • Frequency and timing of resolution of Gd enhancement on MRI

 

Reach out to our expert team, as you are designing and planning your trial.

About IAG, Image Analysis Group

IAG is a unique partner to life sciences companies developing new treatment and driving the hope of the up-coming precision medicine. IAG leverages expertise in medical imaging and the power of DYNAMIKA™, our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner. IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes.

Acting as imaging Contract Research Organization, IAG’s experts also recognize the significance of a comprehensive approach to asset development. They actively engage in co-development projects with both private and public sectors, demonstrating a commitment to cultivating collaboration and advancing healthcare solutions.

Contact our expert team: imaging.experts@ia-grp.com

READ NEXT CASE STUDY >
Experience: Scoring Systems
  • Loes score
  • Gadolinium Intensity Score (GIS) score
  • Develop, validate and implement bespoke scoring methodologies
  • Brain White Matter Volume
  • Brain Lesion Volume
  • Cortical Gray Matter Volume
Experience: Imaging
  • Anatomical MRI (FLAIR, T1, T2)
  • Perfusion MRI (DSC, DCE)
  • Diffusion MRI (ADC, DWI, DTI)
  • SWI
  • MRS
Publications

Since 2007, over 2000 articles were published to cover scientific discoveries, technology break-throughs and special cases. We list here some critically important papers and abstracts.

Testimonials

Combining our technologies and business advisory services with promising life science companies has yielded spectacular results over the past five years. As a trusted partner to many biotech and pharma companies, IAG’s team is proud to share your words and quotes.