TargTex and IAG, Image Analysis Group Announce Partnership

TargTex and IAG, Image Analysis Group Announce Partnership

TargTex and IAG, Image Analysis Group Announce Partnership

Lisbon, Portugal and London, UK, 8 February 2023

TargTex to partner with IAG to apply Artificial Intelligence and Advanced Imaging strategies to assess the effects of a clinical candidate in Recurrent Glioblastoma Patients

TargTex SA, a pre-clinical stage biopharmaceutical company focused on developing localized therapies for solid tumors, and IAG, Image Analysis Group, a leading global medical imaging company, are collaborating to apply Artificial Intelligence (AI) and Quantitative imaging to further the development of TargTex investigational product, a hydrogel dispersed drug nanosuspension used as adjunct-to-surgery in a single dose therapy, in patients with glioblastoma multiforme (GBM).

In this collaboration, the parties will utilize AI and advanced quantitative image analysis to identify early treatment changes in GBM patients and development of predictive response markers.

Advanced imaging techniques could play a critical role in response assessment in developing new and innovative cancer therapies.

Multiparametric magnetic resonance imaging (mpMRI) provides quantitative non-invasive imaging markers of early therapy-related changes.

TargTex foundation is also based on an artificial intelligence algorithm created by one of the founding members that can decipher relationships between biological targets and molecules of interest. They identified a new target for a daunting pathology – GBM. Considering GBM’s particularities, a hydrogel to be used as a neo-adjuvant in a single-dose therapy is being developed as a solution.

IAG’s advanced technology will be crucial for the detection of pseudo-progression, which is difficult to distinguish from true disease progression using routine clinical MRI assessment, avoid early patient withdrawal and save costs. The use of novel image analysis methodologies will allow the partners to address complex issues such as pseudo-progression and quantitatively measure the treatment response, thus deploying a truly precision medicine approach to monitor patient outcomes accurately.

IAG has deep expertise in blinded centralized reading and analysis of patient responses in real-time. IAG’s scientific and medical imaging expertise in GBM, coupled with IAG’s proprietary Artificial Intelligence-powered platform DYNAMIKA, will allow TargTex to review efficacy assessments and explore the drug effect in GBM patients thoroughly.

Dr. João Seixas, CEO of TargTex, said:

“In a complex indication such as GBM it is important for us to have IAG’s expertise in advanced imaging and to employ AI tools to differentiate our program and accelerate our development through the use of predictive response markers.”

Dr. Olga Kubassova, CEO of IAG commented,

“It is our pleasure to support TargTex team who have strong foundation in biology and AI. It is our joint long-term objective to bring TargTex clinical candidates for different oncological indications through clinical development to commercialization.”

About TargTex

 TargTex SA is a Portuguese biotech company that emerged from a blended academic research and medical environment. TargTex’s lead program on GBM is based on a machine learning algorithm that deciphered a relationship between an unexplored target for GBM – calcium channel – and a small molecule with known anticancer properties. From a long-term perspective, TargTex aims to develop clinical candidates for different oncological indications based on localized drug delivery, to prevent post-surgical recurrence and metastasis.

For further information, please visit https://targtex.com/

About IAG

IAG, Image Analysis Group is a unique partner to life sciences companies, leading AI-powered drug development and precision medicine. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner.  IAG provides early drug efficacy assessments, smart patient recruitment, and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view of asset development, bringing R&D solutions, operational breadth, and radiological expertise via risk-sharing financing and partnering models.

For further information, please visit ia-grp.com or reach out to imaging.experts@ia-grp.com

For further information please visit ia-grp.com or reach out to imaging.experts@ia-grp.com

Supporting Advance Imaging Research in Psoriatic Arthritis Treatment

Supporting Advance Imaging Research in Psoriatic Arthritis Treatment

Academic and Clinical Opinion Leaders and Image Analysis Group Collaborate to Advance Research in Psoriatic Arthritis Treatment.

London, UK — Image Analysis Group (wp1.ia-grp.com), a pioneer in medical imaging research and analysis, have joined forces in a strategic collaboration with renowned academic and clinical opinion leaders aimed at advancing research in the treatment of Psoriatic Arthritis, study MOSAIC, ClinicalTrials.gov Identifier: NCT03783026.

Amgen, known for its commitment to innovative therapies, recently presented the results of MOSAIC and its clinically relevant research findings on Otezla (Apremilast) in Psoriatic Arthritis during the European League Against Rheumatism (EULAR) 2023 annual meeting. The study, titled “Apremilast Reduces Inflammation as Measured by MRI of the Hand in Patients With Psoriatic Arthritis: Primary Results from the Phase 4 MOSAIC Study,” showcased the potential of Apremilast in reducing inflammation, as assessed through MRI scans of the hand.

This work is done in collaboration with MOSAIC study Primary Investigators Prof. Mease and Prof. Ostergaard, number of academic institutions and Image Analysis Group, an organization specializing in advanced medical imaging analysis and research.

This phase 4 trial and collected imaging and clinical data mark a significant step forward in drug developers’ mission to improve the lives of individuals affected by Psoriatic Arthritis. By harnessing the expertise and cutting-edge methodologies and advanced technology platform DYNAMIKA, Image Analysis Group and the collaborators aim to explore and quantify the impact of Apremilast on patients’ lives.

Image Analysis Group’s dedication to developing precise and comprehensive imaging solutions aligns seamlessly with Amgen’s commitment to scientific innovation, said Dr. Olga Kubassova, CEO of IAG.

We are excited to work in this trial with this dedicated group of people, so that our expertise in medical imaging analysis can support understanding and treatment of Psoriatic Arthritis, said Prof. Mikael Boesen, Sn Therapeutic Lead for Musculoskeletal Research at IAG and Head of musculoskeletal imaging and research, Bispebjerg and Frederiksberg Hospital, Radiology, Department of Overlæge, Professor, Bispebjerg and Frederiksberg Hospital, The Parker Institute , Denmark.

This work with Amgen and all collaborators signifies a shared vision of improving patient outcomes through innovation and imaging research.

For media inquiries, interview requests, or further information about this collaboration, please contact

imaging.experts@ia-grp.com

About Image Analysis Group: Image Analysis Group (wp1.ia-grp.com) is a leading provider of advanced medical imaging research and analysis services. With a focus on precision and scientific rigor, Image Analysis Group collaborates with pharmaceutical companies, research institutions, and healthcare providers to enhance the understanding of diseases and support the development of novel treatments.

Reach out: imaging.experts@ia-grp.com

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Supportting Advance Imaging Research in Women’s Reproductive Health

Supportting Advance Imaging Research in Women’s Reproductive Health

Ferring Pharmaceuticals and Image Analysis Group Collaborate to Advance Research in the complex field of pregnancy.

London, UK — Image Analysis Group (wp1.ia-grp.com), a leader in medical imaging, have joined forces in a strategic collaboration with Ferring Pharmaceuticals to advance Women’s Reproductive Health through AI-driven medical image analysis.

Dr. Philippe Pinton, Senior Vice President, Head of Clinical and Translational Sciences, Global R&D at Ferring Pharmaceuticals, stated, “Our collaboration with IAG is a testament to our commitment to AI-driven research in the complex field of pregnancy.”

Dr. Olga Kubassova, CEO of IAG, added, “We are excited to support the Ferring team in leveraging AI to gain deeper insights into women’s reproductive health, ultimately aiming to enhance the chances of a healthy pregnancy for women globally.”

IAG’s mission is to assist pharmaceutical partners in efficiently developing transformative medicines. This is achieved through their expertise in medical imaging and AI, utilizing their proprietary platform, DYNAMIKA. This platform is designed to efficiently manage large volumes of imaging data in multi-centre trials and incorporates integrated AI modules. The partnership promises innovative approaches to improve women’s health worldwide.

For media inquiries, interview requests, or further information about this collaboration, please contact

imaging.experts@ia-grp.com

About Image Analysis Group: Image Analysis Group (wp1.ia-grp.com) is a leading advanced medical imaging research and analysis services provider. With a focus on precision and scientific rigour, Image Analysis Group collaborates with pharmaceutical companies, research institutions, and healthcare providers to enhance the understanding of diseases and support the development of novel treatments.

Reach out: imaging.experts@ia-grp.com

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University of Leeds partner with IAG to bring a new AI-driven endpoint into clinical trials

University of Leeds partner with IAG to bring a new AI-driven endpoint into clinical trials

DAVIX – DYNAMIKA’s Novel Endpoint for Measuring Proliferation of Neointima

A collaboration between IAG, Image Analysis Group, the University of Leeds, and Prof. Francesco Del Galdo brings a new AI-driven endpoint into clinical trials.

For immediate release: 21 October 2022

Digital Artery Volume Index (DAVIX©) is a novel quantitative MRI-based scoring for the assessment of the blood flow in the arteries.

DAVIX© has been validated as a predictor of the onset of Digital Ulcers in Systemic Sclerosis patients. This innovative methodology is based on the Time-of-Flight Magnetic Resonance Imaging (MRI) angiography and allows to quantitatively assess digital arterial blood flow.

Thus, predicting the onset of Digital Ulcers (DUs) in Systemic Sclerosis (SSc) patients.

The methodology was developed as part of IAG’s DYNAMIKA cloud platform and is now accessible for use in clinical trials and clinical practice for research use. DAVIX© is being deployed by biotech and pharmaceutical companies in global clinical trials as a surrogate outcome measure of SSc vascular disease activity.

This robust methodology can be delivered to clinical sites, with over 100 imaging sites around the world already acquiring the specific MRI data to allow for the assessment of SSc patients with DAVIX©.

DAVIX© is the first MRI quantitative measure of vascular disease in Systemic Sclerosis. Building on its predictive value for active vascular disease, it is now tested in randomised clinical trials as stratification tool for vascular disease and as a surrogate endpoint for vasoactive interventions,” said Professor Francesco Del Galdo, University of Leeds.

The proprietary name of the endpoint DAVIX© has been copyrighted by the University of Leeds, with a lifetime licence assigned to IAG, Image Analysis Group.

“We look forward to seeing how this unique endpoint will help accelerating the speed of pharmaceutical R&D and most importantly improve therapeutic success for patients,“  said Dr. Olga Kubassova, CEO of IAG, Image Analysis Group.

Neointima proliferation results in vascular wall thickening and gradual loss of luminal patency and is a key pathological feature of Systemic Sclerosis. It is a recognised culprit pathological lesion in Digital Ulcers pulmonary hypertension and renal crisis.

We are delighted with the results of this collaboration. DAVIX© fits perfectly with IAG’s suite of advanced Artificial Intelligence (AI)-supported imaging methodologies and our strategy to make DYNAMIKA™ the leading image management platform for forward thinking drug developers, said Simon Hart, IAG’s Bio-Partnering Director.

IAG’s has brought technical capabilities and over 15 years of operational experience helping to optimize and standardize DAVIX© in clinical trials. This is a great compliment to all IAG’s teams involved into developing and deploying our Artificial Intelligence methodologies, across hundreds of globally distributed clinical sites, built on our DYNAMIKA™, IAG’s proprietary secure cloud based medical image management and review platform, “ added Prof. Jamshid Dehmeshki, CTO of IAG.  

About IAG, Image Analysis Group

IAG, Image Analysis Group is a unique partner to life sciences companies, leading AI-powered drug development and precision medicine. IAG leverages expertise in medical imaging and the power of DYNAMIKA™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner. IAG provides early drug efficacy assessments, smart patient recruitment, and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, and radiological expertise via risk-sharing financing and partnering models.

Reach out: imaging.experts@ia-grp.com
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