IAG & eTheRNA Partner in Immunotherapy Development Effort

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IAG & eTheRNA Partner in Immunotherapy Development Effort

Niel, Belgium and London, UK July 01, 2019

eTheRNA immunotherapies NV, a clinical-stage Belgian company developing mRNA based immunotherapies for the treatment of cancer and IAG, a bio-pharma expert imaging company announced today a a collaboration aimed at facilitating the clinical evaluation of immuno-therapies based on eTheRNA’s proprietary mRNA-based TriMix platform with the use of IAG’s cloud based software DYNAMIKA.

eTheRNA is developing the mRNA-based immunotherapy ECI-006, which is a combination of TriMix (three mRNAs encoding dendritic cell maturation and activation proteins),  and mRNAs coding for 5 tumor-associated antigens. The primary objective of the product is to elicit an immune response against metastatic tumors.

IAG will leverage its proprietary software platform Dynamika for central imaging data logistics and analysis to facilitate the clinical development and standardize image assessment including RECIST 1.1 and iRECIST.

The use of innovative imaging data management and analysis platform DYNAMIKA will enable the partners to ensure that all imaging data is of high-quality as well as maintain control over trial progress.

Dr. Diana Roettger, Head of Therapeutic Innovation at IAG commented:

Well-known image assessment issues in solid tumor clinical trials such as inter- and intra-reader reproducibility will be addressed through optimized workflows and increased transparency to quantitatively measure the treatment response in a fast turnaround.

Having clear and reliable early efficacy signals in our clinical program, which IAG is uniquely positioned to provide, can be a game-changer, particularly for immunotherapies like ECI-006,” stated Dr. Bertil Lindmark, CMO at eTheRNA, Our work with IAG’s imaging expert team will help us better understand how ECI-006’s mechanism of action can affect the tumor development and, ultimately, support our goal of getting the right treatment to the right patients at the right time.”


About eTheRNA immunotherapies NV

eTheRNA immunotherapies NV is a clinical-stage company delivering innovative cancer immunotherapies from its proprietary mRNA-based TriMix platform. eTheRNA’s goal is to commercialise these immunotherapies to deliver long lasting clinical remission to cancer patients. eTheRNA was established in January 2013 as a spin-off from the VUB university in Belgium and is backed by international life science investors. www.etherna.be


About TriMix

The TriMix platform, on which eTheRNA’s immunotherapies NV are based, comprises three mRNAs encoding proteins (caTLR4, CD40L and CD70) that work synergistically to deliver optimal activation of dendritic cells. These cells behave as immune response mediators and mobilize the immune system to attack cancer cells through inducing a T-cell response. Clinical proof of concept for TriMix-based immunotherapies has been established through an extensive dataset demonstrating clear clinical benefits in advanced melanoma patients.


About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner.  IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

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Reach out: imaging.experts@ia-grp.com

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