NEURO-ONCOLOGY

Image Analysis Group (IAG) has a strong focus on neuro-oncology, leveraging its extensive expertise in advanced imaging and clinical trial design to accelerate drug development for brain tumors. IAG’s team specializes in designing and delivering trials aimed at advancing the understanding, diagnosis, and treatment of various brain cancers, including gliomas, ependymomas, glioblastoma multiforme (GBM), and medulloblastomas in both adult and pediatric populations.

IAG’s approach to neuro-oncology encompasses several key areas:

1. Immunotherapy

2. Cancer genetics and genotyping

3. Targeted therapies and precision cancer medicine

4. Radiation and chemotherapy

The company’s scientific advisory board and academic collaborators have made significant contributions to basic and clinical research in understanding brain tumor biology and identifying new therapies. IAG is involved in global consortiums and has led the development of novel imaging endpoints in neuro-oncology.

IAG brings years of oncology, neuro-radiology, and quantitative medical imaging expertise to address the complex challenges associated with brain tumor research, including:

• Tumor heterogeneity

• Complex tumor microenvironment

• Pseudo-progression

• Tumor volume and size changes

• Cellular level response

Understanding the importance of optimal clinical trial design, IAG recommends the most suitable imaging modalities and helps select appropriate trial endpoints. Their team assists in site selection and training, imaging data collection, and review.

IAG is also at the forefront of developing innovative approaches to brain tumor research. For example, they have partnered with McMaster University’s Stem Cell and Cancer Research Institute to develop multi-omics-based machine learning models for studying glioblastoma multiforme. This collaboration aims to create prognostication models using radiomics, proteomics, and transcriptomics to evaluate the microstructural and functional bases of glioblastoma behavior.

By combining advanced imaging techniques with artificial intelligence and machine learning, IAG is working towards precision medicine in neuro-oncology. Their goal is to develop genotypic-phenotypic biomarkers that allow for better risk stratification and improved prognostication of brain tumors, particularly GBM.

IAG’s team has deep understanding of challenges associated with design and execution of neuro-oncology trials.

We understand that optimal clinical trial design is crucial. Chosen imaging modality and associated image analysis will help to prove the efficacy of the therapy. These must show the functional and anatomical structure of the tumour and help addressing the treatment induced changes quantitatively and as early in the process as possible.

We will recommend the optimal imaging and help selecting the trial endpoints. It is often the case that conventional imaging methods such as anatomical MRI in combination with RANO are adequate, but they also may be misdealing. Once the trial is designed, IAG’s team will select and train the sites, assist with imaging data collection and review.

Reach out to our expert team, as you are designing and planning your trial.

About IAG, Image Analysis Group

IAG is a unique partner to life sciences companies developing new treatment and driving the hope of the up-coming precision medicine. IAG leverages expertise in medical imaging and the power of DYNAMIKA™, our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner. IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes.

Acting as imaging Contract Research Organization, IAG’s experts also recognize the significance of a comprehensive approach to asset development. They actively engage in co-development projects with both private and public sectors, demonstrating a commitment to cultivating collaboration and advancing healthcare solutions.

Contact our expert team: imaging.experts@ia-grp.com