IAG to present on Radiomics and Reporter Gene Imaging at RSNA’19


IAG to present on Radiomics and Reporter Gene Imaging at RSNA’19

We are pleased to announce that two abstracts from IAG’s expert team were accepted for presentation at Radiology Society of North America (RSNA), 1-7 December 2019, Chicago, USA.

Reporter Gene Imaging and Its Potential Role in Drug Development, by F Shaikh, MD; E Kurtys, PhD; O A Kubassova, PhD; D Roettger, PhD; T Haywood discussing Reporter Gene Imaging (RGI), which involves imaging of encoding proteins that can be rapidly and sensitively assayed as surrogate markers when fused with regulatory regions of the gene of interest.  This abstract presents how RGI can be used in drug development for pharmacodynamic and pharmacokinetic assessment of cellular, gene, oncolytic viral and immunotherapeutic approaches using MRI, PET, SPECT, Ultrasound, Bioluminescence and Fluoroscence.  Some of the teaching points include further insight into RGI imaging probes that can be direct, indirect or activable; range from enzymes, protein receptors and cell membrane transporters and how RGI qualitatively and quantitatively assesses cell targeting, transfection, protein expression and intracellular processes.

‘Radiomics in Clinical Trials – The Rationale, Current Practices, and Future Considerations’, by F.  Shaikh, MD, PA; D Roettger, PhD; E Kurtys; O A Awan, MD; O A Kubassova, PhD, focused on radiomics, which involves deep quantitative analysis of radiological images for structural and/or functional information.  It is a phenomic assessment of disease to understand lesion microstructure, microenvironment and molecular/cellular function.  In particular, the abstract presents how in oncology, the radiomics can help accurately classify, stratify and prognosticate tumours based on if, how and when they transform, infiltrate, involute or metastasize. We will be sharing case studies on how to integrate radiomics in an imaging-based clinical trials and how to streamline workflow to handle large datasets, robust platforms to accommodate machine learning calculations, and seamless incorporation of derived insights into outcomes matrix.

These abstracts are examples of our ongoing pursuit of scientific excellence in the field of medical imaging by providing cutting edge imaging techniques and quantitative methodologies for assessment of treatment efficacy and vetting them through scientific process for robustness and reproducibility.

IAG’s team will be attending the meeting to discuss novel strategies in drug development that include advanced imaging biomarkers in the clinical development process.

About IAG, Image Analysis Group

IAG partners with biotechnology and pharmaceutical companies and supports clinical research programs with its scientific, operational and technological expertise. IAG takes a holistic approach to biotech’s clinical development and brings together an efficient cloud-based system with embedded quality controls for trial data management (DYNAMIKA), patented methodologies for quantitative assessment of treatment efficacy and safety and expertise to ensure regulatory compliance, drug development and scientific credibility of your data. We ensure that our bio-pharmaceutical clients gain the most benefits of early objective decision making on their treatment efficacy from utilizing advanced imaging techniques in their trials.

Speak to us about your program and discover our risk assessment and management strategies to overcome the challenges in your  trial by contacting IAG at contact@ia-grp.com

About RSNA

The Radiological Society of North America (RSNA) is a non-profit organization with over 54,000 members from 136 countries around the world. It provides high-quality educational resources, including continuing education credits toward physicians’ certification maintenance, host the world’s largest radiology conference and publish two top peer-reviewed journals: Radiology and RadioGraphics. The society is dedicated to building the future of radiology profession, whether that’s through our Research & Education Foundation, which has funded $60 million in grants since its inception, our solutions to support standards development or educational outreach to low-resource nations. https://www.rsna.org/annual-meeting