IAG’s Science Team Publishes Groundbreaking Review on Reporter Gene Imaging in Drug Discovery
IAG’s radiomics team, led by Dr. Faiq Shaikh, has published a seminal Foundation Review article in the prestigious journal Drug Discovery Today (Elsevier), exploring the role of Reporter Gene Imaging (RGI) in translational medicine and drug development.
Key Highlights:
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Novel Technique: RGI is an innovative molecular imaging approach that indirectly images reporter genes to indicate the expression of genes of interest using MRI, PET, or optical imaging probes.
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Translational Potential: While primarily used in preclinical settings, RGI is gaining traction in early drug development, particularly for designing preclinical and early-phase clinical studies.
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Next-Generation Therapeutics: RGI shows promise in pharmacodynamic and pharmacokinetic profiling of novel therapeutic candidates, especially in gene therapy, stem cell therapy, and cancer vaccines.
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Timely Publication: The review comes at an opportune moment as RGI becomes applicable as an exploratory endpoint for immunotherapeutic agents and other advanced therapeutics.
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Comprehensive Overview: The paper discusses RGI’s basic concepts, methodology, challenges, and practical applications in imaging-based drug development.
IAG emphasized the timeliness of this review, noting RGI’s potential as an exploratory endpoint for immunotherapeutic agents and its increasing relevance in translational research.
This publication underscores IAG’s position at the forefront of innovative imaging technologies in drug discovery and development. By leveraging advanced techniques like RGI, IAG continues to provide cutting-edge solutions for pharmaceutical companies seeking to accelerate their drug development processes and improve the success rates of clinical trials.