IAG’s Science Team Just Published on Reporter Gene Imaging in Translational Medicine in Drug Discovery
IAG’s radiomics team headed by Dr. Faiq Shaikh has just published the first article that explores the role of Reporter Gene Imaging in the realm of translational medicine.
The article entitled “Reporter Gene Imaging & Its role in Drug Development” was published as a Foundation Review article by the prestigious journal – Drug Discovery Today (Elsevier).
Reporter gene imaging (RGI) is a novel technique that falls within the domain of molecular imaging and involves indirect imaging of reporter genes that indicate the expression of the genes of interest using molecular probes that can acquired using MRI, PET or optical imaging (bioluminescence, fluorescence imaging).
While this approach remains largely preclinical and therefore restricted with the realm of drug discovery through small animal imaging, there is now an increasing interest in using RGI for early drug development. This comes to light in designing preclinical, phase I and II studies that use RGI for pharmacodynamic and pharmacokinetic profiling of novel therapeutic candidates.
These tend to belong to next-generation therapeutics, such as gene therapy, stem cell therapy and cancer vaccines.
The paper discusses the basic concepts and methodology of RGI, and the challenges and practicability of its application in imaging-based drug development.
‘The timing of this review is opportune as RGI becomes applicable for use as an exploratory endpoint for immunotherapeutic novel agents, and as these next-generation therapeutics enter further into the translational pipeline‘. said Dr. Faiq Shaikh, M.D. – IAG’s Head of Research & Enterprise (Oncology & Radiomics).
About the authors:
Faiq Shaikh, M.D. – IAG’s Head of Research & Enterprise (Oncology & Radiomics) has dual fellowship trained Molecular Imaging physician, informatician and a translational imaging researcher. A UNC- and UPMC-alum, he specializes in the advanced imaging methodologies using machine learning approaches to develop imaging biomarkers for oncologic drug development. He has written over 45 scientific papers, abstracts and book chapters in this area. Other authors include Ewelyna Kurtys, Ph.D., Olga Kubassova, Ph.D. (CEO, IAG) and Diana Dupont-Roettger, Ph.D. (Director of Therapeutic Innovation, IAG).
About Drug Discovery Today (Elsevier):
Drug Discovery Today is a monthly peer-reviewed scientific journal that is published by Elsevier. It was established in 1996 and publishes reviews on all aspects of preclinical drug discovery from target identification and validation through hit identification, lead identification and optimization, to candidate selection. According to the Journal Citation Reports, the journal has a 2018 impact factor of 6.8
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