The goals of imaging in head and neck cancer are to establish tumor extent and size, to assess nodal disease, to evaluate for perineural tumor spread, and to distinguish recurrent tumor from post-treatment changes.

MRI is the preferred modality for assessment of nasopharyngeal, sinonasal, and parotid tumors, because of better contrast resolution, high frequency of perineural spread, and less prominent motion artifacts. MRI is the best modality to delineate the extent of intraorbital and intracranial extension of malignant tumors.

Tumors of the oropharynx, larynx, and hypopharynx are frequently primarily imaged with CT, which is less affected by breathing and swallowing artifacts.

MRI is also the initial study of choice for tumors confined to the oral tongue, and possibly also for other oral cavity locations because MRI is superior in detection of tumor spread into the bone marrow.

Positron emission tomography (PET) is very sensitive for metastatic lymph nodes that are at least 8 mm in size and is the technique of choice in dubious cases. For imaging of treated head and neck cancer, PET scans have been found to generally offer higher sensitivity than MRI or CT.

Combined PET/CT may be the modality of choice because it almost completely eliminates the false-positive and false-negative PET findings. Combining PET with MRI has proven to be technically and clinically more challenging than initially expected and, as such, research into the potential clinical role of PET/MRI in comparison with PET/CT, diffusion-weighted MRI (DW MRI) or the combination thereof is still ongoing.

Experience: Scoring Systems
  • RECIST 1.1
  • PET-based Standard Uptake Value (SUV)
  • Volumetric Assessment
Experience: Imaging
  • CT
  • Anatomical MRI
  • Perfusion Imaging (DCE-MRI, DSC)
  • Diffusion Imaging (ADC, DWI, DTI)
  • Multiparametric MRI (mpMRI)
  • PET/CT

Since 2007, over 2000 articles were published to cover scientific discoveries, technology break-throughs and special cases. We list here some critically important papers and abstracts.


Combining our technologies and business advisory services with promising life science companies has yielded spectacular results over the past five years. As a trusted partner to many biotech and pharma companies, IAG’s team is proud to share your words and quotes.