ONCOLOGY: Fluorescence imaging

ONCOLOGY: Fluorescence imaging

Fluorescence Imaging

Fluorescence imaging utilizes molecules with fluorescent property – fluorophores – that are excited by specific wavelengths of light, depending on the molecular property.

Subsequently, light is re-emitted with less energy but with longer wavelengths.

The penetration depth of the light depends on the wavelengths.

The near-infrared (NIR) spectrum of 700–1200 nm, the so-called “optical window,” has advantages for in vivo fluorescence imaging as there are less photon scattering, less absorption and less autofluorescence from tissue compared to light in the the visual spectrum. Whereas fluorescence in the visual spectrum can be detected by the human eye, fluorescence in the NIR spectrum requires a digital camera system as light in the NIR spectrum it is not visible to the human eye (Vonk et al, 2021).

Fluorescence guided surgery is an intraoperative medical technique used to generate a real-time fluorescence image to guide the surgical procedure for optimal resection of the tumor (Vonk et al, 2021 and Zheng et al, 2019).


About IAG, Image Analysis Group

IAG, Image Analysis Group is a strategic partner to bio-pharmaceutical companies developing new treatments to improve patients’ lives. Our dynamic Strategy, Trial Solutions and Bio-Partnering divisions work closely to meet critical needs of biotechnology companies: funding, clinical development, and monetization of their assets. We fuse decades of therapeutic insights, risk-sharing business model and agile culture to accelerate novel drug development. IAG broadly leverages its core imaging expertise, proprietary technology platform DYNAMIKA and capabilities to support an objective early go no/ go decision and drive excellence for tomorrow’s innovative therapeutic agents with speed.

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Experience: Scoring Systems
  • RANO
  • PET-based Standard Uptake Value (SUV)
  • Volumetric Assessment
Experience: Imaging
  • Fluorescence
  • Anatomical CT / MRI
  • perfusion imaging (DCE-MRI, DSC)
  • diffusion imaging (ADC, DWI, DTI)
  • Multiparametric MRI (mpMRI)
  • PET/CT
  • T-cell Labelling
  • T-Cell Tracing

Since 2007, over 2000 articles were published to cover scientific discoveries, technology break-throughs and special cases. We list here some critically important papers and abstracts.


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