IAG is pleased to announce several publications at the upcoming EULAR 2023 conference. These publications represent IAG’s ongoing commitment to advancing the field of rheumatology through innovative research and collaboration. Join our team and collaborators who will be discussing the value of novel scoring system to improve clinical trials’ outcomes.

“Today, clinical trials require designs and endpoints which can give quick definitive answers about novel treatments in smaller patient cohorts and allow determining competitive edge of a novel drug candidate,” said Olga Kubassova, CEO and co-founder of IAG. “This is a great opportunity to showcase our research and support biotech and pharma collaborators.”

Below is a list of posters and presentations:

• MRI Digital Artery Volume Index (DAVIX©) as quantitative, continuous imaging outcome measure of vascular disease in systemic sclerosis – Poster: POS1336

 

• Efficacy of Apremilast on Whole-Body Inflammation Indices in Patients With Psoriatic Arthritis: Assessments by Whole-Body Magnetic Resonance Imaging in the Phase 4 MOSAIC Study – Publication: AB1535

 

• Apremilast Reduces Inflammation as Measured by MRI of the Hand in Patients With Psoriatic Arthritis: Primary Results from the Phase 4 MOSAIC Study – Poster: POS0226

 

• A Proof of Biological Concept Trial of CM101 to Target CCL24 in Systemic Sclerosis: a Biomarker Informed, Precision Medicine Approach – Publication: AB0808

 

• A Phase 2b double-blind placebo-controlled randomized clinical trial of SB-061, an aggrecan mimetic, in subjects with symptomatic knee osteoarthritis – Poster: POS0104

 

• Five-Year Follow-Up Of A 2-Year Mri Treat-To-Target Strategy On Radiographic Damage Progression In Rheumatoid Arthritis Patients In Clinical Remission – The Imagine-More Study – Poster: POS0052

 

• Intra-Articular Mm-Ii, A Novel Suspension Of Large Empty Multilamellar Liposomes, In Painful Knee Osteoarthritis: A 26 Week Phase 2b Randomized Trial – Poster: POS0106

 

• The Influence Of Baseline Demographics On Variability Of Oa Pain Assessed By Womac Pain Change From Baseline In Interventional Trials – Poster:POS1361

 

• Colchicine Twice Daily For Hand Osteoarthritis: Results From The Double-Blind, Randomised, Placebo-Controlled Color Trial – Presentation: OP0073 

 

• 2023 Update Of Eular Recommendations For The Treatment Of Systemic Sclerosis – Presentation: OP0234

We will provide further updates on the specific details of these publications as they become available.

“It is important to us that our work is accessible to the broader scientific community,” said Prof. Mikael Boesen, chair of Scientific Advisory Board of IAG.

IAG looks forward to participating in EULAR 2023 and contributing to the ongoing advancement of the field of rheumatology.

Join IAG’s scientific team at EULAR 2023, May 30 – June 2 2023, Milan, Italy, at our poster presentations!

About IAG, Image Analysis Group:

IAG, Image Analysis Group is a unique clinical development partner to life sciences companies. We broadly leverage our proprietary image analysis methodologies, power of our cloud platform DYNAMIKA, years of experience in AI and Machine Learning as well as bespoke co-development business models to ensure higher probability for promising therapeutics to reach the patients. Our independent Bio-Partnering division fuses risk-sharing business models and agile culture to accelerate novel drug development. wp1.ia-grp.com

Learn more:  wp1.ia-grp.com

Reach out: imaging.experts@ia-grp.com

Follow the Company: Linkedin

At the DDW next week, IAG’s team will join the discussions about the value of pathology in Ulcerative Colitis and its ability to predict the disease severity and outcomes.

Our 2 presentations, with scientific and industry collaborators cover real-world AI deployment for gastroenterology clinical research and predictive nature of AI Histology in drug development.

IAG, Image Analysis Group, a leader in the field of IA and quantitative imaging for drug development, working across many therapeutic areas.

We deploy AI, our platform DYNAMIKA and global operations to extract meaningful insights from the imaging in clinical trials. We support phase 1-3 trials and special data mining projects, working in partnership with biotech and pharma companies. Examples and case studies of our work are available here: wp1.ia-grp.com

 

IAG’s team and collaborators will present 2 posters at Digestive Disease Week 2023 (DDW2023)

1: DEPLOYMENT OF AN ARTIFICIAL INTELLIGENCE TOOL FOR PRECISION MEDICINE IN ULCERATIVE COLITIS: PRELIMINARY DATA FROM 8 GLOBALLY DISTRIBUTED CLINICAL SITES –  Session date: May 7, 2023;  Session Time: 12:30 PM to 1:30 PM CDT

IAG‘s team together with Takeda Pharmaceuticals and a global panel of gastroenterology and pathology experts support the deployment of AI in gastroenterology practice. The abstract reports how IAG’s Artificial Intelligence (AI) tool was rolled out to 8 globally distributed centres of excellence in Inflammatory Bowel Disease, specifically UC. 600 images were collected and added to the 200 images from the proof of concept phase of the project. The resulting dataset generated over 43,000 characterisations that were used to further train the AI Tool in the segmentation and quantification of cell counts and tissue types and assignment of a Nancy Index disease stage score. The AI Tool was tested by comparing results with a panel of 3 expert human histopathologists and demonstrated over 90% correlation between human and AI, laying the foundations for a novel, AI driven, standardised and quantified mechanism for UC disease stage scoring.

2: A NOVEL AI TOOL IS ACCURATE AT INTERPRETING HISTOLOGY AND DETECTS RESPONSE TO NEIHULIZUMAB THERAPY IN PATIENTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS: PROOF OF CONCEPT – Session date: May 8, 2023;  Session Time: 12:30 PM to 1:30 PM CDT

IAG‘s team together with AltruBio Inc and David T. Rubin MD, report in this abstract the conduct an AI driven retrospective analysis of digitised histology biopsy slides from AltruBio’s Phase IIb study of Neihulizumab (NCT03298022), a novel immune checkpoint agonistic antibody that binds to human CD162 that is being tested in UC and graft versus host disease. Quantitative analyses of cell and tissue types were performed longitudinally at screening and week 12 after 10 doses of Neihulizumab. Results reveal a correlation between disease remission and reduced neutrophil density. AI generated disease stage scores reported using the Nancy Index correlated well (87%) with human readers of the same biopsies.

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Join IAG’s scientific team at DDW 2023, March 6-9 2023, Chicago, USA, at our poster presentations!

About IAG, Image Analysis Group:

IAG, Image Analysis Group is a unique clinical development partner to life sciences companies. We broadly leverage our proprietary image analysis methodologies, power of our cloud platform DYNAMIKA, years of experience in AI and Machine Learning as well as bespoke co-development business models to ensure higher probability for promising therapeutics to reach the patients. Our independent Bio-Partnering division fuses risk-sharing business models and agile culture to accelerate novel drug development. wp1.ia-grp.com

Learn more:  wp1.ia-grp.com

Reach out: imaging.experts@ia-grp.com

Follow the Company: Linkedin

IAG’s team and collaborators will present 2 posters at Digestive Disease Week 2023 (DDW2023)

1: DEPLOYMENT OF AN ARTIFICIAL INTELLIGENCE TOOL FOR PRECISION MEDICINE IN ULCERATIVE COLITIS: PRELIMINARY DATA FROM 8 GLOBALLY DISTRIBUTED CLINICAL SITES –  Session date: May 7, 2023;  Session Time: 12:30 PM to 1:30 PM CDT

IAG‘s team together with Takeda Pharmaceuticals and a global panel of gastroenterology and pathology experts support the deployment of AI in gastroenterology practice. The abstract reports how IAG’s Artificial Intelligence (AI) tool was rolled out to 8 globally distributed centres of excellence in Inflammatory Bowel Disease, specifically UC. 600 images were collected and added to the 200 images from the proof of concept phase of the project. The resulting dataset generated over 43,000 characterisations that were used to further train the AI Tool in the segmentation and quantification of cell counts and tissue types and assignment of a Nancy Index disease stage score. The AI Tool was tested by comparing results with a panel of 3 expert human histopathologists and demonstrated over 90% correlation between human and AI, laying the foundations for a novel, AI driven, standardised and quantified mechanism for UC disease stage scoring.

2: A NOVEL AI TOOL IS ACCURATE AT INTERPRETING HISTOLOGY AND DETECTS RESPONSE TO NEIHULIZUMAB THERAPY IN PATIENTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS: PROOF OF CONCEPT – Session date: May 8, 2023;  Session Time: 12:30 PM to 1:30 PM CDT

IAG‘s team together with AltruBio Inc and David T. Rubin MD, report in this abstract the conduct an AI driven retrospective analysis of digitised histology biopsy slides from AltruBio’s Phase IIb study of Neihulizumab (NCT03298022), a novel immune checkpoint agonistic antibody that binds to human CD162 that is being tested in UC and graft versus host disease. Quantitative analyses of cell and tissue types were performed longitudinally at screening and week 12 after 10 doses of Neihulizumab. Results reveal a correlation between disease remission and reduced neutrophil density. AI generated disease stage scores reported using the Nancy Index correlated well (87%) with human readers of the same biopsies.

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“IAG are pleased to collaborate with world recognised opinion leaders to leverage IAG’s advanced imaging capabilities as we study the potential of AI driven histology to benefit patients with Ulcerative Colitis,” said Dr Olga Kubassova, CEO of IAG, Image Analysis Group.

Join IAG’s scientific team at DDW 2023, March 6-9 2023, Chicago, USA, at our poster presentations!

Mucosal healing is an established treatment target in UC, but not all clinical sites have access to the required resources. The AI Tool has the potential to facilitate rapid, detailed histological assessment in a clinical setting for the benefit of all UC patients” said Simon Hart, Director, Biopartnering, Image Analysis Group.

About IAG, Image Analysis Group:

IAG, Image Analysis Group is a unique clinical development partner to life sciences companies. We broadly leverage our proprietary image analysis methodologies, power of our cloud platform DYNAMIKA, years of experience in AI and Machine Learning as well as bespoke co-development business models to ensure higher probability for promising therapeutics to reach the patients. Our independent Bio-Partnering division fuses risk-sharing business models and agile culture to accelerate novel drug development. wp1.ia-grp.com

Learn more:  wp1.ia-grp.com

Reach out: imaging.experts@ia-grp.com

Follow the Company: Linkedin