DAVIX – Dynamika’s novel endpoint for measuring proliferation of neointima

DAVIX - Dynamika’s novel endpoint for measuring proliferation of neointima

DAVIX – Dynamika’s novel endpoint for measuring proliferation of neointima

A collaboration between IAG and the University of Leeds:

The proprietary process name DAVIX is copyrighted by the University of Leeds, with a non exclusive life time licence assigned to IAG (Image Analysis Group).

Neointima proliferation results in vascular wall thickening and gradual loss of luminal patency and is a key pathological feature of Systemic Sclerosis (SSc). It is a recognised culprit pathological lesion in Digital Ulcers (DU), pulmonary hypertension and renal crisis.

DAVIX, Digital Artery Volume Index, describes an innovative time of flight MRI angiography, quantitatively assessing digital arterial blood flow without the need for contrast administration, predicting the onset of DUs in SSc patients.

DAVIX is being deployed by major biotech and pharmaceutical companies in global clinical trials involving over 100 sites around the world, to measure the degree to which digital blood flow is compromised and to be tested as surrogate outcome measure of SSC vascular disease activity .

DAVIX is the first contrast free, MRI quantitative measure of vascular disease in SSc. Building on its predictive value for active vascular disease, in the context of observational cohorts, it is now tested in the context of randomised clinical trials as stratification tool for vascular disease and as surrogate endpoint for vasoactive interventions” said Professor Francesco Del Galdo, University of Leeds.

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“IAG is delighted to have collaborated with the DAVIX development team.DAVIX fits perfectly with IAG’s suite of advanced AI supported imaging methodologies and endpoints that are being deployed across hundreds of globally distributed clinical sites, underpinned by DYNAMIKA, IAG’s proprietary secure cloud based medical image processing platform, said Dr Olga Kubassova, CEO, IAG (Image Analysis Group)

About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies, leading AI-powered drug development and precision medicine. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner. IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

Learn more: www.ia-grp.com
Reach out: imaging.experts@ia-grp.com
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Live presentation DDW 2022: AI and Precision Medicine in Ulcerative Colitis

Live presentation DDW 2022: AI and Precision Medicine in Ulcerative Colitis

Live presentation DDW 2022: AI and Precision Medicine in Ulcerative Colitis

Join Dr Olga Kubassova, IAG’s CEO, Simon Hart, IAG’s Bio-partnering Director, and key opinion leader Professor Laurent Peyrin-Biroulet (Nancy University Hospital, France) during a live presentation of our collaborative project with Takeda Pharmaceuticals International AG.

“An Artificial Intelligence driven scoring system to measure histological disease activity in Ulcerative Colitis”

Date: 24 May 2022,  2:30 pm PDT

In this live presentation, Professor Laurent Peyrin-Biroulet will discuss the application of IAG’s Artificial Intelligence (AI) driven assessment of histopathology ulcerative colitis images, in the first of a series of collaborative projects between IAG and Takeda.

Join IAG at the presentation, or if you are not attending, schedule a call: imaging.experts@ia-grp.com

About the project

The collaboration is supported by prominent clinical centres and opinion leaders, including sites in Switzerland, France, Canada, USA, Israel, and Portugal.

IAG and Takeda have been working together since 2019 and have developed a novel Artificial Intelligence (AI)-powered method for the assessment of histopathology ulcerative colitis images. The tool will potentially allow practising gastroenterologists to evaluate disease activity with an automated method that is accurate, reproducible and reliable in UC patients. To date, the AI Tool has been trained and tested on 200 images, showing performance comparable to a human expert. As the next step, the partners are engaging eight world-leading sites, who will test the AI Tool in their clinical practices.

Together with our commercial and academic partners, we are excited to be in the position to advance clinical decision-making by bringing better technologies into the play, said Dr. Olga Kubassova, CEO of IAG, Image Analysis Group.

‘Augmenting clinical decision-making with AI in the field of histopathology has the potential to bring great value for management of patients with ulcerative colitis.  Our AI Tool’s ability to provide additional information on the disease state and patient response to a new treatment in real-time gives us ability to gain more insights and make better and faster decisions,’ said Prof. Laurent Peyrin-Biroulet, Department of Hepato-Gastroenterology and Inserm U954, University Hospital of Nancy.

As part of our 30-year commitment to gastroenterology, we recognize the importance of collaborations with digital health leaders, such as IAG, to identify and pursue cutting edge technologies to advance the care of patients.  We see great potential in this initiative and are excited to enter into the next phase of research using deep learning models and AI to support gastroenterologists’ in their patient care”, said Dr. Shashi Adsul, Sr. Director, Global Medical Unit Head at Takeda Pharmaceuticals International AG.

About DDW

Digestive Disease Week (DDW) is the most prestigious meeting in the world for GI professionals providing an unparalleled opportunity to delve into exciting new developments with leaders in gastroenterology, hepatology, endoscopy and gastrointestinal surgery. To find out more about this conference click here.

About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies, leading AI-powered drug development and precision medicine. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner. IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

Learn more: www.ia-grp.com
Reach out: imaging.experts@ia-grp.com
Follow the Company: Linkedin

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Events

Meet IAG’s Team at DDW 2022, San Diego

Meet IAG’s Team at DDW 2022, San Diego

Meet IAG’s Team at DDW 2022, San Diego

Dr. Olga Kubassova, IAG’s CEO, and Simon Hart, IAG’s Bio-partnering Director, will be attending the Digestive Disease Week 2022 (DDW 2022) conference in San Diego, on May 21 – 24, 2022.

IAG’s team will be meeting with key biotech companies and addressing the challenges they face in pharmaceutical trials to explore IAG’s novel strategies, including advanced imaging biomarkers and Artificial Intelligence in precision medicine and drug development.

If you are not attending, schedule a call: imaging.experts@ia-grp.com

IAG partners with biotechnology and pharmaceutical companies and applies AI and Precision Medicine to accelerate drug approval.

IAG takes a holistic approach to biotech’s clinical development and brings together:

  • An efficient purpose-built cloud-based system with embedded quality controls for trial data management (DYNAMIKA)
  • Patented methodologies for quantitative assessment of treatment efficacy and safety
  • Expertise in detecting treatment effects including pseudo-progression and pseudo-response
  • Expertise to ensure regulatory compliance, targeted drug development and scientific credibility of your data
  • Ensures that its bio-pharmaceutical clients gain the greatest benefits from early objective decision making on treatment efficacy from utilizing advanced imaging techniques

Discover our risk assessment and management strategies to overcome the challenges in your trial by contacting IAG at imaging.experts@ia-grp.com

About DDW

Digestive Disease Week (DDW) is the most prestigious meeting in the world for GI professionals providing an unparalleled opportunity to delve into exciting new developments with leaders in gastroenterology, hepatology, endoscopy and gastrointestinal surgery. To find out more about this conference click here.

About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies, leading AI-powered drug development and precision medicine. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner. IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

Learn more: www.ia-grp.com
Reach out: imaging.experts@ia-grp.com
Follow the Company: Linkedin

News
Events

Meet IAG’s Team at EULAR 2022, Copenhagen

Meet IAG’s Team at EULAR 2022, Copenhagen

Meet IAG’s Team at EULAR 2022, Copenhagen

Dr. Olga Kubassova, IAG’s CEO, will be attending the European Congress of Rheumatology (EULAR 2022) in in Copenhagen, on June 1 – 4, 2022.

IAG’s team will be meeting with key biotech companies and addressing the challenges they face in pharmaceutical trials to explore IAG’s novel strategies, including advanced imaging biomarkers and Artificial Intelligence in precision medicine and drug development.

POSTER INFORMATION

Use of Artificial Intelligence and cloud-based infrastructure to improve the speed and accuracy of eligibility reads in osteoarthritis trials. POS1127

M. Boesen, C. Pereira da Costa, J. O’Lynn, A. Patterson, D. Kessler, O. Kubassova

If you are not attending, schedule a call: imaging.experts@ia-grp.com

IAG partners with biotechnology and pharmaceutical companies and applies AI and Precision Medicine to accelerate drug approval.

IAG takes a holistic approach to biotech’s clinical development and brings together:

  • An efficient purpose-built cloud-based system with embedded quality controls for trial data management (DYNAMIKA)
  • Patented methodologies for quantitative assessment of treatment efficacy and safety
  • Expertise in detecting treatment effects including pseudo-progression and pseudo-response
  • Expertise to ensure regulatory compliance, targeted drug development and scientific credibility of your data
  • Ensures that its bio-pharmaceutical clients gain the greatest benefits from early objective decision making on treatment efficacy from utilizing advanced imaging techniques

Discover our risk assessment and management strategies to overcome the challenges in your trial by contacting IAG at imaging.experts@ia-grp.com

About EULAR

European Congress of Rheumatology (EULAR 2022) is one of the the most prestigious meetings in the world for rheumatology providing a forum of an unparalleled opportunity to the highest standard for scientific, both clinical and basic, educational and social exchange between professionals.

To find out more about this conference click here.

About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies, leading AI-powered drug development and precision medicine. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner. IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

Learn more: www.ia-grp.com
Reach out: imaging.experts@ia-grp.com
Follow the Company: Linkedin

News
Events