Genome-wide association meta-analysis indicate differences in genetic associations between knee and hip osteoarthritis depending on joint replacement status. Genetic correlations with pain phenotypes tended to be stronger in the non-surgical groups. For the surgical phenotypes, 10 novel variants were identified, including genes involved in autophagy (rs2447606 in ATG7) and mechanotransduction (rs202127176 in PIEZO1).

Title: Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement

Journal: Annals of the Rheumatic Diseases

Authors: Cecilie Henkel, Mikael Boesen and Anders Troelsen

Access Publication Online: http://dx.doi.org/10.1136/ard-2022-22319

About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner.  IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

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AI-based methods demonstrate feasibility, reliability and validity when utilized to quantify MRI pathologies of peripheral joints in patients with inflammatory arthritis. Computer-aided evaluation could be considered as an alternative to conventional observer-based methods.

Title: Computer-assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta-analysis

Journal: ACR Open Rheumatology: ACROR-21-226.R1

Authors: Arya Haj-Mirzaian, Olga Kubassova, Mikael Boesen, John Carrino and Paul Bird

Access Publication Online: https://journals.lww.com

 

About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner.  IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

Learn more:  wp1.ia-grp.com

Reach out: imaging.experts@ia-grp.com

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AI-based methods demonstrate feasibility, reliability and validity when utilized to quantify MRI pathologies of peripheral joints in patients with inflammatory arthritis; his provides a sound basis for future research. Computer-aided evaluation of inflammatory arthritis on non-CE and CE-MRI, and DCE-MRI could be considered as an alternative to conventional observer-based methods.

Title:Computer-assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta-analysis

Journal: ACR Open Rheumatology: ACROR-21-226.R1

Authors: Arya Haj-Mirzaian, Olga Kubassova, Mikael Boesen, Paul Bird and John Carrino

Access Journal Online: https://journals.lww.com

 

About Image Analysis Group (IAG)

IAG, Image Analysis Group is a unique partner to life sciences companies. IAG leverages expertise in medical imaging and the power of Dynamika™ – our proprietary cloud-based platform, to de-risk clinical development and deliver lifesaving therapies into the hands of patients much sooner.  IAG provides early drug efficacy assessments, smart patient recruitment and predictive analysis of advanced treatment manifestations, thus lowering investment risk and accelerating study outcomes. IAG bio-partnering takes a broader view on asset development bringing R&D solutions, operational breadth, radiological expertise via risk-sharing financing and partnering models.

Learn more:  wp1.ia-grp.com

Reach out: imaging.experts@ia-grp.com

Follow the Company: Linkedin